Bioequivalence and Bioavailability Forum • Sum of residuals ~ ε

Sum of residuals ~ ε [Design Issues]

posted by PharmCat – Russia, 2019-12-24 19:40 (1934 d 02:21 ago) – Posting: # 21028
Views: 8,644

❝ I disagree. In the model ε = 0. However in the fit, the sum of residuals is only asymptotically 0. We shouldn’t speak of bias when we obtain something sufficiently close to the numeric resolution of the machine.

Hi Helmut!

I don't mean that we have bias because 0 not equal eps(). Numericaly we can make calculation with values lower that eps() like: (1E-40 + 2E-40) * 3E+40 = 9.0. Problems can start with things like this: 1 + 1E-40, for example: (1E+40 - 1E+40 + 1 == 1E+40 + 1 - 1E+40) == false. - this not what about a try to say.

I try to say, that zero residual (or effective zero residual) can't be at all, "by definition" in linear model.

Complete thread:

Should those subjects have only one period data be included in BE analysis? ssussu 2019-12-06 10:58 [Design Issues]
- No way! But... Beholder 2019-12-06 12:36
  - No way! But... ElMaestro 2019-12-06 13:14
    - No way! But... Helmut 2019-12-06 14:47
      - No way! But... PharmCat 2019-12-06 23:46
        
        No way! But... wienui 2019-12-07 04:01
        
        EMA guideline: no way...: mittyri 2019-12-07 20:58
        
        EMA guideline: no way...: wienui 2019-12-09 05:25
        
        Slightly off topic, but related :-) ElMaestro 2019-12-08 01:31
        
        Slightly off topic, but related :-) Shuanghe 2019-12-09 12:00
        Slightly off topic, but related :-) PharmCat 2019-12-09 15:13
        
        Slightly off topic, but related :-) ElMaestro 2019-12-21 15:02
        
        Slightly off topic, but related :-) PharmCat 2019-12-22 01:12
        2.220446e-16 ≈ 0 Helmut 2019-12-22 10:37
        
        The optional tolerance argument ElMaestro 2019-12-23 14:37
        2.220446e-16 ≈ 0 PharmCat 2019-12-24 14:18
        
        Sum of residuals ~ ε Helmut 2019-12-24 14:54
        
        Sum of residuals ~ ε ElMaestro 2019-12-24 15:10
        
        Wrong terminology Helmut 2019-12-28 13:55
        
        Sum of residuals ~ εPharmCat 2019-12-24 18:40