Bioequivalence and Bioavailability Forum • Sum of residuals ~ ε

Sum of residuals ~ ε [Design Issues]

posted by Helmut – Vienna, Austria, 2019-12-24 14:54 (703 d 10:15 ago) – Posting: # 21026
Views: 4,200

Hi PharmCat

» I suppose hat this value come from QR decomposition with pivoting of rank deficient X matrix. So real value = 0. Can residual of random variable be equal zero? - No => bias.

I disagree. In the model ε = 0. However in the fit, the sum of residuals is only asymptotically 0. We shouldn’t speak of bias when we obtain something sufficiently close to the numeric resolution of the machine.

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Helmut Schütz

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Complete thread:

Should those subjects have only one period data be included in BE analysis? ssussu 2019-12-06 10:58 [Design Issues]
- No way! But... Beholder 2019-12-06 12:36
  - No way! But... ElMaestro 2019-12-06 13:14
    - No way! But... Helmut 2019-12-06 14:47
      - No way! But... PharmCat 2019-12-06 23:46
        
        No way! But... wienui 2019-12-07 04:01
        
        EMA guideline: no way...: mittyri 2019-12-07 20:58
        
        EMA guideline: no way...: wienui 2019-12-09 05:25
        
        Slightly off topic, but related :-) ElMaestro 2019-12-08 01:31
        
        Slightly off topic, but related :-) Shuanghe 2019-12-09 12:00
        Slightly off topic, but related :-) PharmCat 2019-12-09 15:13
        
        Slightly off topic, but related :-) ElMaestro 2019-12-21 15:02
        
        Slightly off topic, but related :-) PharmCat 2019-12-22 01:12
        2.220446e-16 ≈ 0 Helmut 2019-12-22 10:37
        
        The optional tolerance argument ElMaestro 2019-12-23 14:37
        2.220446e-16 ≈ 0 PharmCat 2019-12-24 14:18
        
        Sum of residuals ~ εHelmut 2019-12-24 14:54
        
        Sum of residuals ~ ε ElMaestro 2019-12-24 15:10
        
        Wrong terminology Helmut 2019-12-28 13:55
        
        Sum of residuals ~ ε PharmCat 2019-12-24 18:40