Slightly off topic, but related :-) [Design Issues]

posted by ElMaestro  – Belgium?, 2019-12-21 15:02 (312 d 05:45 ago) – Posting: # 21012
Views: 3,074

Hi PharmCat,

» For observation 8 we have -3.608225e-16, I think,

This. I think, is around the "effective zero" for fits in R at default settings on 64- and 32-bit systems.

» I don't know how to say with сlever words.

Very unfortunate, because I did not understand what was being said. I would like to get the insight. It is at the limits of my conception.

» ML and REML variation estimates all biased, but less biased than lm with missing data.

Is this a fact? How do we actually know this? Do you have a reference I coud learn from (not Pinheiro and Bates, I don't understand a word of it).
Does "less biased" apply to both the fixed effects and to the variance components?

I could be wrong, but...

Best regards,
ElMaestro

No, of course you do not need to audit your CRO if it was inspected in 1968 by the agency of Crabongostan.

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