Slightly off topic, but related :-) [Design Issues]

posted by ElMaestro  – Denmark, 2019-12-21 15:02 (971 d 05:22 ago) – Posting: # 21012
Views: 4,913

Hi PharmCat,

» For observation 8 we have -3.608225e-16, I think,

This. I think, is around the "effective zero" for fits in R at default settings on 64- and 32-bit systems.

» I don't know how to say with сlever words.

Very unfortunate, because I did not understand what was being said. I would like to get the insight. It is at the limits of my conception.

» ML and REML variation estimates all biased, but less biased than lm with missing data.

Is this a fact? How do we actually know this? Do you have a reference I coud learn from (not Pinheiro and Bates, I don't understand a word of it).
Does "less biased" apply to both the fixed effects and to the variance components?

Pass or fail!

Complete thread:

UA Flag
 Admin contact
22,305 posts in 4,668 threads, 1,587 registered users;
online 9 (0 registered, 9 guests [including 8 identified bots]).
Forum time: Thursday 21:24 CEST (Europe/Vienna)

On two occasions I have been asked,—“Pray, Mr. Babbage,
if you put into the machine wrong figures,…
will the right answers come out?”
I am not able rightly to apprehend the kind of confusion of ideas
that could provoke such a question.    Charles Babbage

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz