Slightly off topic, but related :-) [Design Issues]

posted by ElMaestro  – Denmark, 2019-12-21 16:02 (1074 d 17:27 ago) – Posting: # 21012
Views: 4,967

Hi PharmCat,

❝ For observation 8 we have -3.608225e-16, I think,


This. I think, is around the "effective zero" for fits in R at default settings on 64- and 32-bit systems.

❝ I don't know how to say with сlever words.


Very unfortunate, because I did not understand what was being said. I would like to get the insight. It is at the limits of my conception.

❝ ML and REML variation estimates all biased, but less biased than lm with missing data.


Is this a fact? How do we actually know this? Do you have a reference I coud learn from (not Pinheiro and Bates, I don't understand a word of it).
Does "less biased" apply to both the fixed effects and to the variance components?

Pass or fail!
ElMaestro

Complete thread:

UA Flag
Activity
 Admin contact
22,418 posts in 4,693 threads, 1,598 registered users;
15 visitors (0 registered, 15 guests [including 9 identified bots]).
Forum time: 09:29 CET (Europe/Vienna)

Intellect distinguishes between the possible and the impossible;
reason distinguishes between the sensible and the senseless.
Even the possible can be senseless.    Max Born

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5