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RegisterGroup effect, did you miss it? [General Statistics]
Dear Friends!
Recently I've known that Belorussian experts referring to EAEC rules require to recalculate the results of large studies using FDA's Model II, that is: Group, Sequence, Treatment, Period(Group), Group×Sequence as fixed and Subject(Group×Sequence) as Random though it was not stated in protocol beforehand.
I don't think it is a good idea. Moreover it could be contagious! What do you think about it?
Critical points: as standard model requires Sequence, Treatment, Period and Subject(Sequence) as fixed terms, the results of the random effect model obviously will be different. What if they will change the overall result of BE? What if the Group×Sequence effect would be significant by chance?
How to deal with excluded subjects? For example, if we have a subject with only one period the fixed-effect model would automatically neglect it while the random-effect model would use it.
As I understand currently it is impossible to calculate it via R, isn't it? May be Julia will help? So only people with commercial software could deal with it.
Recently I've known that Belorussian experts referring to EAEC rules require to recalculate the results of large studies using FDA's Model II, that is: Group, Sequence, Treatment, Period(Group), Group×Sequence as fixed and Subject(Group×Sequence) as Random though it was not stated in protocol beforehand.
I don't think it is a good idea. Moreover it could be contagious! What do you think about it?
Critical points: as standard model requires Sequence, Treatment, Period and Subject(Sequence) as fixed terms, the results of the random effect model obviously will be different. What if they will change the overall result of BE? What if the Group×Sequence effect would be significant by chance?
How to deal with excluded subjects? For example, if we have a subject with only one period the fixed-effect model would automatically neglect it while the random-effect model would use it.
As I understand currently it is impossible to calculate it via R, isn't it? May be Julia will help? So only people with commercial software could deal with it.
—
"Being in minority, even a minority of one, did not make you mad"
"Being in minority, even a minority of one, did not make you mad"
Complete thread:
- Group by sequence interaction Mutasim 2019-08-07 13:16 [General Statistics]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Group by sequence interaction, an urban myth? Helmut 2019-08-07 14:35
- pristine, genuine, holy, magnificent, inexplicable beautiful variation ElMaestro 2019-08-08 10:06
- I love your subject line! Helmut 2019-08-08 10:31
- Group effect, did you miss it?Astea 2019-12-21 14:12
- Group effect, did you miss it? PharmCat 2019-12-22 01:37
- Group effect: the endless story Helmut 2019-12-22 10:30
- Group effect: the endless river Astea 2019-12-22 21:23
- Group effect: the endless river PharmCat 2019-12-22 22:52
- replicateBE solution with interactions mittyri 2019-12-23 14:30
- replicateBE solution with interactions Astea 2019-12-23 17:26
- datasets issues mittyri 2019-12-24 10:53
- datasets Helmut 2019-12-24 11:03
- datasets Astea 2019-12-24 19:18
- lmer / lme Helmut 2019-12-25 19:12
- datasets Astea 2019-12-24 19:18
- replicateBE solution with interactions Astea 2019-12-23 17:26
- Group effect: the endless river Astea 2019-12-22 21:23
- What do you mean exactly? Beholder 2019-12-27 13:44
- What do you mean exactly? Astea 2019-12-29 21:59
- ANOVA acc. to GL Helmut 2019-12-30 12:32
- What do you mean exactly? Astea 2019-12-29 21:59
- Group effect, did you miss it?Astea 2019-12-21 14:12
- I love your subject line! Helmut 2019-08-08 10:31
- pristine, genuine, holy, magnificent, inexplicable beautiful variation ElMaestro 2019-08-08 10:06
- Group by sequence interaction, an urban myth? Helmut 2019-08-07 14:35
Ing. Helmut Schütz