x ◦ y = y ◦ x? [Design Issues]
Hi ElMaestro,
» while it is hard to disagree with the complex math behind "1×2 ≠ 2×1", …
The
commutative law \(x\circ y=y\circ x\) holds only on the premise of strict linear pharmacokinetics.
» … this is nevertheless how some drugs are approved when originators shift from twice daily to once daily dosing, …
Sure, why not? As usual, know your drug and know your formulation.
» while it is hard to disagree with the complex math behind "1×2 ≠ 2×1", …
The
![[image]](https://static.bebac.at/img/Favicon_wikipedia_en.gif)
» … this is nevertheless how some drugs are approved when originators shift from twice daily to once daily dosing, …
Sure, why not? As usual, know your drug and know your formulation.

—
Dif-tor heh smusma 🖖
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
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Dif-tor heh smusma 🖖
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- BE study design issue jag009 2019-12-13 23:26 [Design Issues]