## x ◦ y = y ◦ x? [Design Issues]

Hi ElMaestro,

» while it is hard to disagree with the complex math behind "1×2 ≠ 2×1", …

The  commutative law $$x\circ y=y\circ x$$ holds only on the premise of strict linear pharmacokinetics.

» … this is nevertheless how some drugs are approved when originators shift from twice daily to once daily dosing, …

Sure, why not? As usual, know your drug and know your formulation.

Dif-tor heh smusma 🖖
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
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