Bioequivalence and Bioavailability Forum

x ◦ y = y ◦ x? [Design Issues]

posted by Helmut  – Vienna, Austria, 2019-12-16 11:00 (1013 d 12:05 ago) – Posting: # 20979
Views: 2,812

Hi ElMaestro,

» while it is hard to disagree with the complex math behind "1×2 ≠ 2×1", …

The commutative law \(x\circ y=y\circ x\) holds only on the premise of strict linear pharmacokinetics.

» … this is nevertheless how some drugs are approved when originators shift from twice daily to once daily dosing, …

Sure, why not? As usual, know your drug and know your formulation.

—
Dif-tor heh smusma 🖖 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
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Complete thread:

• BE study design issue jag009 2019-12-13 23:26 [Design Issues] 
  • 1×2 ≠ 2×1 Helmut 2019-12-14 00:42
    • 1×2 ≠ 2×1 jag009 2019-12-15 19:39
      • 1×2 ≠ 2×1 ElMaestro 2019-12-15 22:02
        • x ◦ y = y ◦ x?Helmut 2019-12-16 11:00
  • BE study design issue Dr_Dan 2019-12-18 15:04
    • ER vs. IR Helmut 2019-12-18 15:33
      • ER vs. IR Dr_Dan 2019-12-19 09:01