Cmax ER = Cmax IR ? [Regulatives / Guidelines]

posted by jag009  – NJ, 2019-12-09 18:15 (294 d 05:18 ago) – Posting: # 20967
Views: 1,685

Hi,

» We have: four maximums and four minimums for IR and one maximum and one minimum for ER

If I understand your question correctly... In general, your trough (Cmin) for ER should be similar (or above) your Cmin of the IR in terms of level (is your a 24hr once daily? If so, then the Cmin of ER at 24 should be similar to Cmin of IR at 24). Your ER should also show less fluctuation than IR (you should).

J

Complete thread:

Activity
 Admin contact
21,084 posts in 4,398 threads, 1,468 registered users;
online 2 (0 registered, 2 guests [including 2 identified bots]).
Forum time: Tuesday 00:33 CEST (Europe/Vienna)

To know the history of science is to recognize the mortality
of any claim to universal truth.    Evelyn Fox Keller

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5