No way! But... [Design Issues]

posted by PharmCat  – Russia, 2019-12-06 23:46 (448 d 02:10 ago) – Posting: # 20954
Views: 3,780

Hi all!

» Correct. If we would be allowed (pun!) to use a mixed-effects model. Patterson and Jones argued against this doubtful practice and the ethical implications of discarding data.

Really, there is no problem in mixed model approach to use all data if model constructed correctly. May be not all regulatory bodies can understand how it works - it is not rare situations when I get issue like "Give me ANOVA!!! I don't want to see your GLM or MIXED...", pfff... or "In guideline ***(any ancient as mammoth's excrement guideline) written ratio of geometric means - please just divide one to another and give me CI"... So here two answers - theoretically there is no problem to use all data, but regulatory authorities can bann you for it. (IMHO)

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