No way! But... [Design Issues]
Ahoy my capt’n and welcome back to this side of the pond!
Those days when studies were evaluated by a paired t-test with a pocket calculator?
Correct. If we would be allowed (pun!) to use a mixed-effects model. Patterson and Jones argued against this doubtful practice and the ethical implications of discarding data.*
❝ I do not know why there is a regulatory tradition for only using completers …
Those days when studies were evaluated by a paired t-test with a pocket calculator?
❝ – I would say there is even a potential scientific and ethical advantage of using all period data.
Correct. If we would be allowed (pun!) to use a mixed-effects model. Patterson and Jones argued against this doubtful practice and the ethical implications of discarding data.*
- Patterson SD, Jones B. Viewpoint: observations on scaled average bioequivalence. Pharm Stat. 2011;11(1):1–7. doi:10.1002/pst.498.
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Should those subjects have only one period data be included in BE analysis? ssussu 2019-12-06 10:58 [Design Issues]
- No way! But... Beholder 2019-12-06 12:36
- No way! But... ElMaestro 2019-12-06 13:14
- No way! But...Helmut 2019-12-06 14:47
- No way! But... PharmCat 2019-12-06 23:46
- No way! But... wienui 2019-12-07 04:01
- EMA guideline: no way...: mittyri 2019-12-07 20:58
- EMA guideline: no way...: wienui 2019-12-09 05:25
- EMA guideline: no way...: mittyri 2019-12-07 20:58
- Slightly off topic, but related :-) ElMaestro 2019-12-08 01:31
- Slightly off topic, but related :-) Shuanghe 2019-12-09 12:00
- Slightly off topic, but related :-) PharmCat 2019-12-09 15:13
- Slightly off topic, but related :-) ElMaestro 2019-12-21 15:02
- Slightly off topic, but related :-) PharmCat 2019-12-22 01:12
- 2.220446e-16 ≈ 0 Helmut 2019-12-22 10:37
- The optional tolerance argument ElMaestro 2019-12-23 14:37
- 2.220446e-16 ≈ 0 PharmCat 2019-12-24 14:18
- Sum of residuals ~ ε Helmut 2019-12-24 14:54
- Sum of residuals ~ ε ElMaestro 2019-12-24 15:10
- Wrong terminology Helmut 2019-12-28 13:55
- Sum of residuals ~ ε PharmCat 2019-12-24 18:40
- Sum of residuals ~ ε ElMaestro 2019-12-24 15:10
- Sum of residuals ~ ε Helmut 2019-12-24 14:54
- Slightly off topic, but related :-) ElMaestro 2019-12-21 15:02
- No way! But... wienui 2019-12-07 04:01
- No way! But... PharmCat 2019-12-06 23:46
- No way! But...Helmut 2019-12-06 14:47
- No way! But... ElMaestro 2019-12-06 13:14
- No way! But... Beholder 2019-12-06 12:36