No way! But... [Design Issues]

posted by ElMaestro  – Denmark, 2019-12-06 14:14 (1544 d 00:13 ago) – Posting: # 20941
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Hello, both,

❝ ❝ At this situation, should this subject's data with one period be included in the BE assessment?


❝ No, you could not.


We do not need a T-R comparison in each subject to do an analysis. We are just stuck in that paradigm. We could in principle fit a model with missing period data. And all data could be used for the calculation of the CI.
I do not know why there is a regulatory tradition for only using completers - I would say there is even a potential scientific and ethical advantage of using all period data.

Pass or fail!
ElMaestro

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