Bioequivalence and Bioavailability Forum

Hi PharmCat,

my deepest respect for the work you have done! Julia is a nasty beast (IMHO, more than SAS and R combined). 

❝ […] Covariance structure: CSH (Type C).

OK, the FDA’s guidance states:

    PROC MIXED;
    CLASSES SEQ SUBJ PER TRT;
    MODEL Y = SEQ PER TRT/ DDFM=SATTERTH;
    RANDOM TRT/TYPE=FA0(2) SUB=SUBJ G;
    REPEATED/GRP=TRT SUB=SUBJ;
    ESTIMATE 'T vs. R' TRT 1 -1/CL ALPHA=0.1;

In the Random statement, TYPE=FA0(2) could possibly be replaced by TYPE=CSH.

(my emphasis)

In some of our reference datasets (and terrible ones posted by John in the forum) of the partial replicate TRR|RTR|RRT we ran into convergence issues with FA0(2) but never with FA0(1) and CSH. Do I understand correctly that you have given up to support partial replicates as all?