Fieller’s (‘fiducial’) confidence interval [General Statistics]
❝ For such cases we are setting
logscale to False, right?
Correct in so far if we use the approximation that the estimate of µR is (statistically) greater than zero. A very reasonable assumption for the usual metrics AUC and Cmax IMHO.
But this has than nothing to do with Fieller’s (‘fiducial’) confidence interval, a more correct method for deriving a confidence interval for the ratio of untransformed PK metrics.
PowerTOST has for this case the functions
Have a look into the man pages of these functions and notice that these functions don't have a
❝ I will read up on the other stuff. Still not sure how to derive the CI. ...
Hauschke D, Steinijans VW, Pigeot I.
Bioequivalence Studies in Drug Development
Chichester: John Wiley; 2007
Especially chapter 10 Equivalence assessment for clinical endpoints.
If you don't own this book, gimme a hint.
- On CI calculation, untransformed metrics ElMaestro 2019-11-29 03:40 [General Statistics]
- Fieller’s (‘fiducial’) confidence interval Helmut 2019-11-29 10:03
- On CI calculation, untransformed metrics PharmCat 2019-11-29 12:05