Bioequivalence and Bioavailability Forum

Fieller’s (‘fiducial’) confidence interval [General Sta­tis­tics]

posted by ElMaestro  – Denmark, 2019-11-29 16:53 (2396 d 18:07 ago) – Posting: # 20897
Views: 7,361

Hi Hötzi,

❝ Nope.

For such cases we are setting logscale to False, right?
PowerTOST says about theta1: "Defaults to 0.8 if logscale=TRUE or to -0.2 if logscale=FALSE. "
So as I read it, when logscale=F theta1 defaults to -.2 or we set it to something negative. This is how I think Hauchke's f1 and theta1 get confused.

I will read up on the other stuff. Still not sure how to derive the CI. it is a really interesting problem, though. Feels like going back into a discussion which was closed decades ago before I knew anything about BE

Thanks PharmCat for the ref. below.

Complete thread:

• On CI calculation, untransformed metrics ElMaestro 2019-11-29 03:40 [General Sta­tis­tics] 
  • Fieller’s (‘fiducial’) confidence interval Helmut 2019-11-29 10:03
    • Fieller’s (‘fiducial’) confidence intervalElMaestro 2019-11-29 15:53
      • Fieller’s (‘fiducial’) confidence interval d_labes 2019-11-29 17:20
        • Fieller’s (‘fiducial’) confidence interval ElMaestro 2019-11-30 05:11
          • power.TOST with logscale=FALSE d_labes 2019-11-30 14:01
        • Fieller’s (‘fiducial’) confidence interval apapanas 2026-03-12 10:54
  • On CI calculation, untransformed metrics PharmCat 2019-11-29 12:05