Metformin and linaglibtin film coated tablet [Bioanalytics]

posted by Ibrahim Komeil – Egypt, 2019-11-28 15:48  – Posting: # 20888
Views: 1,142

Hi

Thank you for your kind reply

Actually i face a problem in the bioanalysis for linaglibtin tablets, i optimized the LLOQ for Linaglibtin to 25 pg/ml and still i see low Cmax reaching 0.7 ng/ml. Additionally the terminal elimination phase is too low knowing that linaglibtin half life is approximately 100 hours while it appeared to be about 24 hours in my analysis

So i doubt about the method of linaglibtin extraction from plasma, so can you tell me which method did you use in sample preparation i think there is an issue here.

BR,

Ibrahim


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5[Helmut]

Complete thread:

Activity
 Admin contact
20,801 posts in 4,354 threads, 1,446 registered users;
online 8 (0 registered, 8 guests [including 6 identified bots]).
Forum time: 23:33 CEST (Europe/Vienna)

If a man will begin with certainties, he will end in doubts;
but if he will be content to begin with doubts,
he will end in certainties.    Francis Bacon

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5