Metformin and linaglibtin film coated tablet [Bioanalytics]

posted by Ibrahim Komeil – Egypt, 2019-11-28 16:48 (2055 d 16:09 ago) – Posting: # 20888
Views: 4,019

Hi

Thank you for your kind reply

Actually i face a problem in the bioanalysis for linaglibtin tablets, i optimized the LLOQ for Linaglibtin to 25 pg/ml and still i see low Cmax reaching 0.7 ng/ml. Additionally the terminal elimination phase is too low knowing that linaglibtin half life is approximately 100 hours while it appeared to be about 24 hours in my analysis

So i doubt about the method of linaglibtin extraction from plasma, so can you tell me which method did you use in sample preparation i think there is an issue here.

BR,

Ibrahim


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5[Helmut]

Complete thread:

UA Flag
Activity
 Admin contact
23,436 posts in 4,932 threads, 1,677 registered users;
57 visitors (0 registered, 57 guests [including 14 identified bots]).
Forum time: 09:58 CEST (Europe/Vienna)

You can’t fix by analysis
what you bungled by design.    Richard J. Light, Judith D. Singer, John B. Willett

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5