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RegisterMetformin and linaglibtin film coated tablet [Bioanalytics]
Hi
Thank you for your kind reply
Actually i face a problem in the bioanalysis for linaglibtin tablets, i optimized the LLOQ for Linaglibtin to 25 pg/ml and still i see low Cmax reaching 0.7 ng/ml. Additionally the terminal elimination phase is too low knowing that linaglibtin half life is approximately 100 hours while it appeared to be about 24 hours in my analysis
So i doubt about the method of linaglibtin extraction from plasma, so can you tell me which method did you use in sample preparation i think there is an issue here.
BR,
Ibrahim
Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]
Thank you for your kind reply
Actually i face a problem in the bioanalysis for linaglibtin tablets, i optimized the LLOQ for Linaglibtin to 25 pg/ml and still i see low Cmax reaching 0.7 ng/ml. Additionally the terminal elimination phase is too low knowing that linaglibtin half life is approximately 100 hours while it appeared to be about 24 hours in my analysis
So i doubt about the method of linaglibtin extraction from plasma, so can you tell me which method did you use in sample preparation i think there is an issue here.
BR,
Ibrahim
Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]
Complete thread:
- Metformin and linaglibtin film coated tablet Ibrahim Komeil 2019-10-19 02:18 [Bioanalytics]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Metformin and linaglibtin film coated tablet hirenmistri 2019-11-28 10:51
- Metformin and linaglibtin film coated tabletIbrahim Komeil 2019-11-28 15:48
- Metformin and linaglibtin film coated tablet hirenmistri 2019-11-28 10:51
Ing. Helmut Schütz