Which package? [🇷 for BE/BA]

posted by sury – India, 2019-11-22 08:23 (1588 d 21:40 ago) – Posting: # 20858
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❝ which package did you use in R (PKNCA or bear)? If the former, did you specify PKNCA.options(auc.method = "lin up/log down")?


i have calculate using Bear package

❝ Your results for WinNonlin look similar to what I got in PHX with the linear trapezoidal:


Subject Period AUClast-R  AUC last-Winnonlin
   1       1    9352.581      9352.188       
   1       2    7965.182      7965.461       
   2       1    8153.202      8152.938       
   2       2   11230.876     11230.466       
   3       1   11156.603     11156.603       
   3       2   10008.454     10008.096       
   4       1    6673.169      6673.368       
   4       2    8652.151      8652.151

Even i have got the same results in the bear package results when i tried all Linear method. the results are not matching after the decimals. The concern is it may impact the 90% CI in border range? is this difference after decimal point accepted?

❝ Why not identical? Which version of WinNonlin? Did you use the scheduled instead of the actual times?


WinNonlin Version 6.4. Actual time was considered in calculation

Thanks for the manual calculation provided. It helped me a lot


Edit: Standard quotes restored; see also this post #8[Helmut]

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