Bioequivalence and Bioavailability Forum • Which package?

Which package? [🇷 for BE/BA]

posted by sury – India, 2019-11-22 08:23 (1980 d 15:52 ago) – Posting: # 20858
Views: 6,754

❝ which package did you use in R (PKNCA or bear)? If the former, did you specify PKNCA.options(auc.method = "lin up/log down")?

i have calculate using Bear package

❝ Your results for WinNonlin look similar to what I got in PHX with the linear trapezoidal:

Subject Period AUClast-R  AUC last-Winnonlin

   1       1    9352.581      9352.188       

   1       2    7965.182      7965.461       

   2       1    8153.202      8152.938       

   2       2   11230.876     11230.466       

   3       1   11156.603     11156.603       

   3       2   10008.454     10008.096       

   4       1    6673.169      6673.368        

   4       2    8652.151      8652.151

Even i have got the same results in the bear package results when i tried all Linear method. the results are not matching after the decimals. The concern is it may impact the 90% CI in border range? is this difference after decimal point accepted?

❝ Why not identical? Which version of WinNonlin? Did you use the scheduled instead of the actual times?

WinNonlin Version 6.4. Actual time was considered in calculation

Thanks for the manual calculation provided. It helped me a lot

Edit: Standard quotes restored; see also this post #8. [Helmut]

Complete thread:

PKNCA Package usage sury 2019-11-20 10:21 [🇷 for BE/BA]
- Data? Helmut 2019-11-20 10:27
  - Data? sury 2019-11-20 11:01
    - Data Helmut 2019-11-20 11:34
      - Data sury 2019-11-20 12:09
- PKNCA Package usage yjlee168 2019-11-20 14:35
  - PKNCA Package usage sury 2019-11-21 05:10
    - Which package? Helmut 2019-11-21 14:53
      - Which package?sury 2019-11-22 07:23
        
        Phoenix 6.3 – 8.1 = bear 2.8.6 = PKNCA 0.9.1 Helmut 2019-11-22 11:22