Which package? [R for BE/BA]

posted by Helmut Homepage – Vienna, Austria, 2019-11-21 14:53 (513 d 10:25 ago) – Posting: # 20854
Views: 3,071

Hi Sury,

which package did you use in R (PKNCA or bear)? If the former, did you specify PKNCA.options(auc.method = "lin up/log down")?

Your results for WinNonlin look similar to what I got in PHX with the linear trapezoidal:
Subject Period   AUClast
   1       1    9352.581
   1       2    7965.182
   2       1    8153.202
   2       2   11230.876
   3       1   11156.603
   3       2   10008.454
   4       1    6673.169
   4       2    8652.151

Why not identical? Which version of WinNonlin? Did you use the scheduled instead of the actual times?

Let’s perform a manual calculation (subject 1, period 1): $$AUC_{lin}|_{t_1}^{t_2}=(t_2-t_1)\frac{C_1+C_2}{2}$$ $$AUC_{log}|_{t_1}^{t_2}=(t_2-t_1)\frac{C_2-C_1}{\log (\frac{C_2}{C_1})}$$  t      C    Ci≥Ci-1? AUCi (lin) Ci<Ci-1? AUCi (log)     AUCi
────────────────────────────────────────────────────────────
 0.00   0.000             0.0                 0.0        0.0
 0.25  96.642   yes      12.1        no                 12.1
 0.50 148.051   yes      30.6        no                 30.6
 1.00 348.997   yes     124.3        no                124.3
 1.50 342.736    no                 yes      172.9     172.9
 2.00 306.647    no                 yes      162.2     162.2
 2.50 282.846    no                 yes      147.3     147.3
 3.02 266.988    no                 yes      142.9     142.9
 4.00 231.600    no                 yes      243.9     243.9
 6.00 171.607    no                 yes      400.2     400.2
 8.00 173.596   yes     345.2        no                345.2
12.00 147.069    no                 yes      639.9     639.9
24.00 145.951    no                 yes     1758.1    1758.1
36.00 117.608    no                 yes     1575.2    1575.2
48.00 108.564    no                 yes     1356.3    1356.3
72.17  75.920    no                 yes     2206.0    2206.0
────────────────────────────────────────────────────────────
                                               AUC0–t  9317.1

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