Bioequivalence and Bioavailability Forum • PKNCA Package usage

PKNCA Package usage [🇷 for BE/BA]

posted by sury – India, 2019-11-21 06:10 (1611 d 18:05 ago) – Posting: # 20850
Views: 5,140

❝ Which method did you use for AUC calculation with bear? 'linear-up/log-down' or 'all linear' trapezoidal method? The default method in bear is 'linear-up/log-down'.

I have use linear-up/log-down method for AUC calculation. below is the data generated in WinNonlin and R bear Package

Subject Period    R-AUCt     R-AUCinf WinNonlin-AUCt WinNonlin-AUCinf

   1       1    9317.106476 15103.284    9352.188       15137.961

   1       2    7931.885043 13851.668    7965.461       13885.461

   2       1    8126.054035 14298.195    8152.938       14324.487

   2       2   11214.85059  28845.668   11230.466       28859.529

   3       1   11087.56862  15754.516   11156.603       15823.550

   3       2    9949.515006 14900.874   10008.096       14959.400

   4       1    6637.356467  9395.552    6673.368        9431.681

   4       2    8610.507473 12694.266    8652.151       12735.910

❝ The other issue to cause the difference is the method used to estimate lambda z.

Adjusted R2 method has been used for the estimation of lambda z.

Edit: Tabulators changed to spaces and BBcoded; see also this post #6. [Helmut]

Complete thread:

PKNCA Package usage sury 2019-11-20 10:21 [🇷 for BE/BA]
- Data? Helmut 2019-11-20 10:27
  - Data? sury 2019-11-20 11:01
    - Data Helmut 2019-11-20 11:34
      - Data sury 2019-11-20 12:09
- PKNCA Package usage yjlee168 2019-11-20 14:35
  - PKNCA Package usagesury 2019-11-21 05:10
    - Which package? Helmut 2019-11-21 14:53
      - Which package? sury 2019-11-22 07:23
        
        Phoenix 6.3 – 8.1 = bear 2.8.6 = PKNCA 0.9.1 Helmut 2019-11-22 11:22