PKNCA Package usage [🇷 for BE/BA]

posted by sury – India, 2019-11-21 05:10 (1001 d 15:21 ago) – Posting: # 20850
Views: 4,044

» Which method did you use for AUC calculation with bear? 'linear-up/log-down' or 'all linear' trapezoidal method? The default method in bear is 'linear-up/log-down'.

I have use linear-up/log-down method for AUC calculation. below is the data generated in WinNonlin and R bear Package

Subject Period    R-AUCt     R-AUCinf WinNonlin-AUCt WinNonlin-AUCinf
   1       1    9317.106476 15103.284    9352.188       15137.961
   1       2    7931.885043 13851.668    7965.461       13885.461
   2       1    8126.054035 14298.195    8152.938       14324.487
   2       2   11214.85059  28845.668   11230.466       28859.529
   3       1   11087.56862  15754.516   11156.603       15823.550
   3       2    9949.515006 14900.874   10008.096       14959.400
   4       1    6637.356467  9395.552    6673.368        9431.681
   4       2    8610.507473 12694.266    8652.151       12735.910


» The other issue to cause the difference is the method used to estimate lambda z.

Adjusted R2 method has been used for the estimation of lambda z.


Edit: Tabulators changed to spaces and BBcoded; see also this post #6[Helmut]

Complete thread:

UA Flag
Activity
 Admin contact
22,305 posts in 4,668 threads, 1,587 registered users;
online 8 (0 registered, 8 guests [including 6 identified bots]).
Forum time: Thursday 21:31 CEST (Europe/Vienna)

On two occasions I have been asked,—“Pray, Mr. Babbage,
if you put into the machine wrong figures,…
will the right answers come out?”
 …
I am not able rightly to apprehend the kind of confusion of ideas
that could provoke such a question.    Charles Babbage

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5