PKNCA Package usage [R for BE/BA]

posted by sury – India, 2019-11-21 05:10  – Posting: # 20850
Views: 796

» Which method did you use for AUC calculation with bear? 'linear-up/log-down' or 'all linear' trapezoidal method? The default method in bear is 'linear-up/log-down'.

I have use linear-up/log-down method for AUC calculation. below is the data generated in WinNonlin and R bear Package

Subject Period    R-AUCt     R-AUCinf WinNonlin-AUCt WinNonlin-AUCinf
   1       1    9317.106476 15103.284    9352.188       15137.961
   1       2    7931.885043 13851.668    7965.461       13885.461
   2       1    8126.054035 14298.195    8152.938       14324.487
   2       2   11214.85059  28845.668   11230.466       28859.529
   3       1   11087.56862  15754.516   11156.603       15823.550
   3       2    9949.515006 14900.874   10008.096       14959.400
   4       1    6637.356467  9395.552    6673.368        9431.681
   4       2    8610.507473 12694.266    8652.151       12735.910


» The other issue to cause the difference is the method used to estimate lambda z.

Adjusted R2 method has been used for the estimation of lambda z.


Edit: Tabulators changed to spaces and BBcoded; see also this post #6[Helmut]

Complete thread:

Activity
 Admin contact
20,101 posts in 4,243 threads, 1,382 registered users;
online 10 (0 registered, 10 guests [including 6 identified bots]).
Forum time (Europe/Vienna): 21:25 CET

Trust, but verify.    Anonymous (Russian proverb)

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5