PKNCA Package usage [🇷 for BE/BA]
❝ Which method did you use for AUC calculation with bear? 'linear-up/log-down' or 'all linear' trapezoidal method? The default method in bear is 'linear-up/log-down'.
I have use linear-up/log-down method for AUC calculation. below is the data generated in WinNonlin and R bear Package
Subject Period R-AUCt R-AUCinf WinNonlin-AUCt WinNonlin-AUCinf
1 1 9317.106476 15103.284 9352.188 15137.961
1 2 7931.885043 13851.668 7965.461 13885.461
2 1 8126.054035 14298.195 8152.938 14324.487
2 2 11214.85059 28845.668 11230.466 28859.529
3 1 11087.56862 15754.516 11156.603 15823.550
3 2 9949.515006 14900.874 10008.096 14959.400
4 1 6637.356467 9395.552 6673.368 9431.681
4 2 8610.507473 12694.266 8652.151 12735.910
❝ The other issue to cause the difference is the method used to estimate lambda z.
Adjusted R2 method has been used for the estimation of lambda z.
Edit: Tabulators changed to spaces and BBcoded; see also this post #6. [Helmut]
Complete thread:
- PKNCA Package usage sury 2019-11-20 10:21 [🇷 for BE/BA]
- Data? Helmut 2019-11-20 10:27
- PKNCA Package usage yjlee168 2019-11-20 14:35
- PKNCA Package usagesury 2019-11-21 05:10
- Which package? Helmut 2019-11-21 14:53
- Which package? sury 2019-11-22 07:23
- Phoenix 6.3 – 8.1 = bear 2.8.6 = PKNCA 0.9.1 Helmut 2019-11-22 11:22
- Which package? sury 2019-11-22 07:23
- Which package? Helmut 2019-11-21 14:53
- PKNCA Package usagesury 2019-11-21 05:10