PKNCA Package usage [🇷 for BE/BA]

posted by yjlee168 Homepage – Kaohsiung, Taiwan, 2019-11-20 15:35 (1608 d 22:10 ago) – Posting: # 20840
Views: 5,194

Hi sury

❝ ...

❝ And i have tried to estimate the PK parameters using BEAR package. but it is not getting the same results as that of the WinNonlin


Which method did you use for AUC calculation with bear? 'linear-up/log-down' or 'all linear' trapezoidal method? The default method in bear is 'linear-up/log-down'. The other issue to cause the difference is the method used to estimate lambda z.

All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

UA Flag
Activity
 Admin contact
22,984 posts in 4,822 threads, 1,650 registered users;
47 visitors (0 registered, 47 guests [including 2 identified bots]).
Forum time: 14:46 CEST (Europe/Vienna)

You can’t fix by analysis
what you bungled by design.    Richard J. Light, Judith D. Singer, John B. Willett

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5