Bioequivalence and Bioavailability Forum • PKNCA Package usage

PKNCA Package usage [R for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2019-11-20 14:35 (740 d 07:04 ago) – Posting: # 20840
Views: 3,638

Hi sury

» ...
» And i have tried to estimate the PK parameters using BEAR package. but it is not getting the same results as that of the WinNonlin

Which method did you use for AUC calculation with bear? 'linear-up/log-down' or 'all linear' trapezoidal method? The default method in bear is 'linear-up/log-down'. The other issue to cause the difference is the method used to estimate lambda z.

—
All the best,
-- Yung-jin Lee
bear v2.9.0:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan http://pkpd.kmu.edu.tw/bear
Download link (updated) -> here

Complete thread:

PKNCA Package usage sury 2019-11-20 10:21 [R for BE/BA]
- Data? Helmut 2019-11-20 10:27
  - Data? sury 2019-11-20 11:01
    - Data Helmut 2019-11-20 11:34
      - Data sury 2019-11-20 12:09
- PKNCA Package usageyjlee168 2019-11-20 14:35
  - PKNCA Package usage sury 2019-11-21 05:10
    - Which package? Helmut 2019-11-21 14:53
      - Which package? sury 2019-11-22 07:23
        
        Phoenix 6.3 – 8.1 = bear 2.8.6 = PKNCA 0.9.1 Helmut 2019-11-22 11:22