PKNCA Package usage [R for BE/BA]

posted by yjlee168 Homepage – Kaohsiung, Taiwan, 2019-11-20 14:35  – Posting: # 20840
Views: 1,127

Hi sury

» ...
» And i have tried to estimate the PK parameters using BEAR package. but it is not getting the same results as that of the WinNonlin

Which method did you use for AUC calculation with bear? 'linear-up/log-down' or 'all linear' trapezoidal method? The default method in bear is 'linear-up/log-down'. The other issue to cause the difference is the method used to estimate lambda z.

All the best,
-- Yung-jin Lee
bear v2.8.7:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan http://pkpd.kmu.edu.tw/bear
Download link (updated) -> here

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