Not more on IS response variations [Regulatives / Guidelines]

posted by nobody – 2019-11-13 10:06  – Posting: # 20797
Views: 987

Not a key opinion leader in this field, but:

I like discussions along the line "problem -> solution". So: if the LLOQ is rock solid, the calibration function stable and the QCs don't indicate a problem, why should I take care of day-to-day variations in IS response too much?

If have had cases where different lab people (in the good old days of liquid-liquid extraction, though...) could produce different IS response with absolute same equipment, solutions, protocols to follow. Why bother to much, as long the quality of the method/validation covers that?

Kindest regards, nobody

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