Bioequivalence and Bioavailability Forum

More on IS response variations [Regulatives / Guidelines]

posted by Helmut  – Vienna, Austria, 2019-11-12 13:41  – Posting: # 20791
Views: 1,057

Hi ElMaestro,

» As a general rule the S:N become more unfavourable as the column ages and peak separation suffers. This affects the identifcation of peaks and their integration. It will be more pronounced for the analyte near the LLOQ than for the IS.

I stand corrected.

—
Cheers,
Helmut Schütz


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Complete thread:

• IS response variations Ohlbe 2019-09-04 19:03 [Regulatives / Guidelines] 
  • IS response variations nobody 2019-09-06 16:21
  • More on IS response variations Ohlbe 2019-11-12 11:32
    • More on IS response variations ElMaestro 2019-11-12 12:27
      • More on IS response variations Helmut 2019-11-12 13:24
        • More on IS response variations ElMaestro 2019-11-12 13:38
          • More on IS response variationsHelmut 2019-11-12 13:41
        • More on IS response variations Ohlbe 2019-11-12 13:56
          • More on IS response variations ElMaestro 2019-11-12 16:25
            • More on IS response variations Ohlbe 2019-11-12 18:14
              • More on IS response variations ElMaestro 2019-11-12 18:39
                • Not more on IS response variations Ohlbe 2019-11-13 00:06
                  • Not more on IS response variations nobody 2019-11-13 10:06
                    • the run passes = there is no problem? ElMaestro 2019-11-13 17:35
                      • the run passes = there is no problem? nobody 2019-11-13 19:17