More on IS response variations [Regulatives / Guidelines]

posted by Helmut Homepage – Vienna, Austria, 2019-11-12 13:41  – Posting: # 20791
Views: 1,057

Hi ElMaestro,

» As a general rule the S:N become more unfavourable as the column ages and peak separation suffers. This affects the identifcation of peaks and their integration. It will be more pronounced for the analyte near the LLOQ than for the IS.

I stand corrected. :-D

Cheers,
Helmut Schütz
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