More on IS response variations [Regulatives / Guidelines]

posted by ElMaestro  – Belgium?, 2019-11-12 13:38 (323 d 11:56 ago) – Posting: # 20790
Views: 2,778

Hi Hötzi,

» I don’t see how that can affect the IS (and analyte) response unless someone works with peak heights (who does it nowadays?)…

As a general rule the S:N become more unfavourable as the column ages and peak separation suffers. This affects the identifcation of peaks and their integration. It will be more pronounced for the analyte near the LLOQ than for the IS.

I could be wrong, but...

Best regards,

R's base package has 274 reserved words and operators, along with 1761 functions. I can use 18 of them (about 14 of them properly). I believe this makes me the Donald Trump of programming.

Complete thread:

 Admin contact
21,090 posts in 4,398 threads, 1,469 registered users;
online 18 (0 registered, 18 guests [including 10 identified bots]).
Forum time: Thursday 02:35 CEST (Europe/Vienna)

In these days, a man who says a thing cannot be done
is quite apt to be interrupted by some idiot doing it.    Elbert Green Hubbard

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz