More on IS response variations [Regulatives / Guidelines]

posted by ElMaestro  – Belgium?, 2019-11-12 12:38  – Posting: # 20790
Views: 1,286

Hi Hötzi,

» I don’t see how that can affect the IS (and analyte) response unless someone works with peak heights (who does it nowadays?)…

As a general rule the S:N become more unfavourable as the column ages and peak separation suffers. This affects the identifcation of peaks and their integration. It will be more pronounced for the analyte near the LLOQ than for the IS.

Le tits now.

Best regards,
ElMaestro

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