Bioequivalence and Bioavailability Forum • More on IS response variations

More on IS response variations [Regulatives / Guidelines]

posted by Helmut – Vienna, Austria, 2019-11-12 14:24 (1620 d 14:51 ago) – Posting: # 20789
Views: 4,126

Hi ElMaestro,

❝ […] At other CROs the IS may be rock solid between runs, and it is of course somewhat equipment and analyte-dependent and factors like column age play a role.

I don’t see how that can affect the IS (and analyte) response unless someone works with peak heights (who does it nowadays?)…

❝ […] "perhaps it is the ion source blah"

If a stable isotope labeled internal standard is used, that’s the only reasonable explanation for me.

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Complete thread:

IS response variations Ohlbe 2019-09-04 19:03 [Regulatives / Guidelines]
- IS response variations nobody 2019-09-06 16:21
- More on IS response variations Ohlbe 2019-11-12 11:32
  - More on IS response variations ElMaestro 2019-11-12 12:27
    - More on IS response variationsHelmut 2019-11-12 13:24
      - More on IS response variations ElMaestro 2019-11-12 13:38
        
        More on IS response variations Helmut 2019-11-12 13:41
      - More on IS response variations Ohlbe 2019-11-12 13:56
        
        More on IS response variations ElMaestro 2019-11-12 16:25
        
        More on IS response variations Ohlbe 2019-11-12 18:14
        
        More on IS response variations ElMaestro 2019-11-12 18:39
        
        Not more on IS response variations Ohlbe 2019-11-13 00:06
        
        Not more on IS response variations nobody 2019-11-13 10:06
        
        the run passes = there is no problem? ElMaestro 2019-11-13 17:35
        
        the run passes = there is no problem? nobody 2019-11-13 19:17