More on IS response variations [Regulatives / Guidelines]

posted by Helmut Homepage – Vienna, Austria, 2019-11-12 13:24 (476 d 17:44 ago) – Posting: # 20789
Views: 2,999

Hi ElMaestro,

» […] At other CROs the IS may be rock solid between runs, and it is of course somewhat equipment and analyte-dependent and factors like column age play a role.

I don’t see how that can affect the IS (and analyte) response unless someone works with peak heights (who does it nowadays?)…

» […] "perhaps it is the ion source blah"

If a stable isotope labeled internal standard is used, that’s the only reasonable explanation for me.

Dif-tor heh smusma 🖖
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
21,359 posts in 4,460 threads, 1,492 registered users;
online 4 (0 registered, 4 guests [including 4 identified bots]).
Forum time: Wednesday 07:09 CET (Europe/Vienna)

The art and science of asking questions
is the source of all knowledge.    Thomas Berger

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5