More on IS response variations [Regulatives / Guidelines]

posted by Helmut Homepage – Vienna, Austria, 2019-11-12 14:24 (1568 d 04:08 ago) – Posting: # 20789
Views: 3,935

Hi ElMaestro,

❝ […] At other CROs the IS may be rock solid between runs, and it is of course somewhat equipment and analyte-dependent and factors like column age play a role.


I don’t see how that can affect the IS (and analyte) response unless someone works with peak heights (who does it nowadays?)…

❝ […] "perhaps it is the ion source blah"


If a stable isotope labeled internal standard is used, that’s the only reasonable explanation for me.

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,912 posts in 4,806 threads, 1,636 registered users;
25 visitors (0 registered, 25 guests [including 4 identified bots]).
Forum time: 18:33 CET (Europe/Vienna)

It is the peculiar and perpetual error of the human understanding
to be more moved and excited by affirmatives than negatives.    Francis Bacon

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5