More on IS response variations [Regulatives / Guidelines]

posted by Helmut Homepage – Vienna, Austria, 2019-11-12 13:24  – Posting: # 20789
Views: 1,080

Hi ElMaestro,

» […] At other CROs the IS may be rock solid between runs, and it is of course somewhat equipment and analyte-dependent and factors like column age play a role.

I don’t see how that can affect the IS (and analyte) response unless someone works with peak heights (who does it nowadays?)…

» […] "perhaps it is the ion source blah"

If a stable isotope labeled internal standard is used, that’s the only reasonable explanation for me.

Cheers,
Helmut Schütz
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