More on IS response variations [Regulatives / Guidelines]

posted by Helmut Homepage – Vienna, Austria, 2019-11-12 14:24 (2067 d 05:12 ago) – Posting: # 20789
Views: 6,293

Hi ElMaestro,

❝ […] At other CROs the IS may be rock solid between runs, and it is of course somewhat equipment and analyte-dependent and factors like column age play a role.


I don’t see how that can affect the IS (and analyte) response unless someone works with peak heights (who does it nowadays?)…

❝ […] "perhaps it is the ion source blah"


If a stable isotope labeled internal standard is used, that’s the only reasonable explanation for me.

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
23,430 posts in 4,931 threads, 1,679 registered users;
56 visitors (0 registered, 56 guests [including 12 identified bots]).
Forum time: 20:37 CEST (Europe/Vienna)

To know that we know what we know,
and to know that we do not know what we do not know,
that is true knowledge.    Nicolaus Copernicus

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5