More on IS response variations [Regulatives / Guidelines]

posted by Helmut Homepage – Vienna, Austria, 2019-11-12 14:24 (1182 d 16:06 ago) – Posting: # 20789
Views: 3,640

Hi ElMaestro,

❝ […] At other CROs the IS may be rock solid between runs, and it is of course somewhat equipment and analyte-dependent and factors like column age play a role.


I don’t see how that can affect the IS (and analyte) response unless someone works with peak heights (who does it nowadays?)…

❝ […] "perhaps it is the ion source blah"


If a stable isotope labeled internal standard is used, that’s the only reasonable explanation for me.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,481 posts in 4,710 threads, 1,603 registered users;
23 visitors (0 registered, 23 guests [including 12 identified bots]).
Forum time: 06:31 CET (Europe/Vienna)

The difference between a surrogate and a true endpoint
is like the difference between a cheque and cash.
You can get the cheque earlier but then,
of course, it might bounce.    Stephen Senn

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5