Bioequivalence and Bioavailability Forum • SAS vs. SAS vs. Phoenix

SAS vs. SAS vs. Phoenix [RSABE / ABEL]

posted by Helmut – Vienna, Austria, 2019-11-12 14:01 (1620 d 22:35 ago) – Posting: # 20788
Views: 8,147

Hi to all victims of the partial replicate with incomplete data,

following extensive off-list discussions with PharmCat (who is working on a Julia-library; see here and there) I checked again what we got with the FDA’s covariance structure, Satterthwaite’s df (PE, 90% CI).
Not the slightest idea how I arrived at the results given above. Sorry for the confusion caused.

John’s first dataset.
- John (SAS, v?)
  101.021 80.7739 – 126.343
- Shuanghe (SAS, v?)
  101.021 80.7733 – 126.3450
- Detlew (SAS, v9.2)
  101.0213 80.7733 – 126.3450
- Myself (Phoenix v6.3 and v8.1)
  No convergence with the default setup.
  However, when I lowered the convergence criterion to 1E-11:
  101.0213 80.7733 – 126.3450
John’s second dataset (ln AUCi).
- John (SAS, v?)
  No convergence.
- Myself (Phoenix v6.3 and v8.1)
  Convergence with warning, tweaking the setup doesn’t help.
  95.2967 88.4014 – 102.7298
  Compound symmetry (as suggested by Detlew)
  95.2967 88.4014 – 102.7298
- Detlew (SAS, v9.2, CS)
  95.30 88.23 – 102.82

In all cases simplifying the covariance structure (in SAS-lingo FA0(1) instead of the FA0(2) in the guidance): Convergence without warning.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

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Science Quotes

Complete thread:

FDA's HVD SAS Code from Progesterone Guidance jag009 2013-04-22 16:39
- Proc MIXED vs. Proc GLM Helmut 2013-04-22 17:47
  - Proc MIXED vs. Proc GLM jag009 2013-04-22 20:33
    - SAS vs. PHX Helmut 2013-04-22 22:10
      - SAS vs. PHX Shuanghe 2013-04-23 11:45
        
        SAS vs. SAS d_labes 2013-04-23 16:50
        
        SAS vs. SAS vs. PhoenixHelmut 2019-11-12 13:01
      - SAS vs. PHX jag009 2013-04-23 15:56
        
        SAS Warning (Note) on Proc Mixed jag009 2013-04-23 17:07
        
        Nut Job.. jag009 2013-04-30 21:09
        
        Second opinion (PHX 6.3) Helmut 2013-05-01 16:21
        
        Second opinion (PHX 6.3) jag009 2013-05-01 17:16
        
        Second opinion (PHX 6.3) ElMaestro 2013-05-01 18:48
        In praise of a full replicate Helmut 2013-05-01 19:16
        Third opinion d_labes 2013-05-02 12:00
        
        Compound Symmetry Helmut 2013-05-02 14:41
        
        Compound Symmetry - SASian (1) d_labes 2013-05-02 16:26
        
        Variance=0 Helmut 2013-05-03 16:07