Kenward-Roger? [RSABE / ABEL]

posted by PharmCat  – Russia, 2019-11-06 14:43  – Posting: # 20755
Views: 3,958

» From a theoretical perspective, maybe. The Kenward-Roger approximation recovers more information from the data, higher degrees of freedom and hence, results in a narrower confidence interval than with Satterthwaite’s degrees of freedom. Since the latter is explicitely recommended in the progesterone guidance I have some doubts whether the FDA would accept that.

I thought that Kenward-Roger provide the same DF as Satterthwaite's for one-dimension effects, so as CI for coefficient is one-dimension hypothesis DF should be the same, as it describes in reference paper, may be SAS make any corrections, I don't know... Is any comparations anywhere?

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