Kenward-Roger? [RSABE / ABEL]

posted by Helmut Homepage – Vienna, Austria, 2019-11-06 12:49 (477 d 18:59 ago) – Posting: # 20754
Views: 5,438

Hi Mahmoud,

» if you need to take into account the missing data use proc mixed in SAS with dffm=Kr

From a theoretical perspective, maybe. The Kenward-Roger approximation recovers more information from the data, higher degrees of freedom and hence, results in a narrower confidence interval than with Satterthwaite’s degrees of freedom. Since the latter is explicitly recommended in the progesterone guidance I have some doubts whether the FDA would accept that.

» otherwise use proc glm in SAS, this procedure do not take into account the missing data


Dif-tor heh smusma 🖖
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

 Admin contact
21,356 posts in 4,458 threads, 1,493 registered users;
online 3 (1 registered, 2 guests [including 2 identified bots]).
Forum time: Friday 07:48 CET (Europe/Vienna)

Those who make no mistakes are making the biggest mistakes of all 
they are attempting nothing new.    Anthony de Mello

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz