Log in
RegisterVery, very strange! [General Statistics]
posted by Helmut 
– Vienna, Austria, 2019-10-31 15:36 (1802 d 21:06 ago) – Posting: # 20738
Views: 5,407
a very interesting observation!
I could confirm that in Phoenix WinNonlin 8.1 (multiplied the first T value of the EMA’s reference data sets by 10). The geometric least squares mean of R changed in data set I (full replicate) but not in data set II (partial replicate).
I also checked the EMA’s methods (simple ANOVA). Similar.
Respective first rows original data, second ones T changed.
─────────────────────────────────
model
─────────────────────────────────
data set RSABE R T
─────────────────────────────────
I 2144.00 2479.70
2143.04 2517.74
II 2852.54 2917.13
2852.54 3074.12
───────────────────────────────────────────────────
Method A Method B
───────────────────────────────────────────────────
ABEL R T R T
───────────────────────────────────────────────────
I 2140.84 2476.07 2143.11 2480.22
2140.18 2513.57 2142.71 2518.22
II 2852.54 2917.13 2852.54 2917.13
2852.54 3210.87 2852.54 3210.87
───────────────────────────────────────────────────
Beyond me.
PS: Differences between RSABE and ABEL are to be expected in case of incomplete data. For the FDA incomplete data are dropped but kept for the EMA.
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Least square mean calculation for the fully replicate design Jaimik Patel 2019-10-31 11:19 [General Statistics]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Very, very strange!Helmut 2019-10-31 14:36
- Very, very strange! Shuanghe 2019-10-31 19:43
- Very, very strange! Helmut 2019-10-31 19:50
- Very, very strange! Jaimik Patel 2019-11-02 12:26
- G matrix mittyri 2019-11-03 01:38
- Very, very strange! Shuanghe 2019-10-31 19:43
- Inner workings of REML ElMaestro 2019-10-31 19:48
- Even in ANOVA… Helmut 2019-10-31 19:53
- Even in 2x2... zizou 2019-11-01 21:05
- trying to understand emmeans mittyri 2019-11-02 02:26
- Even in 2x2... zizou 2019-11-01 21:05
- Even in ANOVA… Helmut 2019-10-31 19:53
- Least square mean calculation for the fully replicate design PharmCat 2019-11-03 00:46
- Very, very strange!Helmut 2019-10-31 14:36
Ing. Helmut Schütz