Very, very strange! [General Sta­tis­tics]

posted by Helmut Homepage – Vienna, Austria, 2019-10-31 14:36  – Posting: # 20738
Views: 511

Hi Jaimik,

a very interesting observation!

I could confirm that in Phoenix WinNonlin 8.1 (multiplied the first T value of the EMA’s reference data sets by 10). The geometric least squares mean of R changed in data set I (full replicate) but not in data set II (partial replicate).
I also checked the EMA’s methods (simple ANOVA). Similar.

Respective first rows original data, second ones T changed.

─────────────────────────────────
          model       
─────────────────────────────────
data set  RSABE      R        T   
─────────────────────────────────
I                2144.00  2479.70   
                 2143.04  2517.74   
II               2852.54  2917.13   
                 2852.54  3074.12   
───────────────────────────────────────────────────
                      Method A          Method B 
───────────────────────────────────────────────────
          ABEL       R        T        R        T
───────────────────────────────────────────────────
I                2140.84  2476.07  2143.11  2480.22
                 2140.18  2513.57  2142.71  2518.22
II               2852.54  2917.13  2852.54  2917.13
                 2852.54  3210.87  2852.54  3210.87
───────────────────────────────────────────────────


Beyond me. :confused:


PS: Differences between RSABE and ABEL are to be expected in case of incomplete data. For the FDA incomplete data are dropped but kept for the EMA.

Cheers,
Helmut Schütz
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