Bioequivalence and Bioavailability Forum

AUC-apical? [Software]

posted by Aisha.ma – United Arab Emirates, 2019-10-07 20:43 (1660 d 17:02 ago) – Posting: # 20677
Views: 3,796

Hi Helmut,

❝ BTW, are you referring to this guideline?

Maybe the sponsor had consult this guideline before designing the study . Gir is the glucose-infusion rate.

❝ Just to clarify: Are you interested in the yellow area?

❝

❝ Doesn’t look like your GIR cause that’s a PK profile but you get the idea. IIRC, this was called AUC_apical by the “Two Lászlós” (Endrényi and Tóthfalusi). Have to dig it out.

I need to know time to 50% of GIR-AUC0-8. At the begining, I think that I can use summary table from Phoenix resluts and the function of AUC to get this time, but I am not sure whether this idea is right.
I have search many meterials about glucose-infsion study, this parameter is the secondary end. So it is a common parameter in glucose-infsion study, but I can not find the calculating mathod.

Complete thread:

• how to get t50%GIR-AUC(0-8h) in winnolin? Aisha.ma 2019-10-07 07:46 [Software] 
  • POT-50 Helmut 2019-10-07 09:52
    • POT-50 Aisha.ma 2019-10-07 16:12
      • AUC-apical? Helmut 2019-10-07 16:58
        • AUC-apical?Aisha.ma 2019-10-07 18:43
          • Define your terms! Helmut 2019-10-07 18:54
            • Define your terms! Aisha.ma 2019-10-07 19:02
              • Define your terms! nobody 2019-10-08 10:51