AUC-apical? [Software]

posted by Aisha.ma – United Arab Emirates, 2019-10-07 18:43  – Posting: # 20677
Views: 321

Hi Helmut,

» BTW, are you referring to this guideline?

Maybe the sponsor had consult this guideline before designing the study . Gir is the glucose-infusion rate.

» Just to clarify: Are you interested in the yellow area?
»

[image]


» Doesn’t look like your GIR cause that’s a PK profile but you get the idea. IIRC, this was called AUCapical by the “Two Lászlós” (Endrényi and Tóthfalusi). Have to dig it out.

I need to know time to 50% of GIR-AUC0-8. At the begining, I think that I can use summary table from Phoenix resluts and the function of AUC to get this time, but I am not sure whether this idea is right.
I have search many meterials about glucose-infsion study, this parameter is the secondary end. So it is a common parameter in glucose-infsion study, but I can not find the calculating mathod.:-(

Complete thread:

Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
19,897 posts in 4,215 threads, 1,366 registered users;
online 9 (0 registered, 9 guests [including 7 identified bots]).
Forum time (Europe/Vienna): 02:06 CEST

A mathematician is a blind man
in a dark room looking for a black cat
which isn’t there.    attributed to Charles Darwin

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5