AUC-apical? [Software]

posted by Aisha.ma – United Arab Emirates, 2019-10-07 20:43 (1719 d 05:04 ago) – Posting: # 20677
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Hi Helmut,

❝ BTW, are you referring to this guideline?


Maybe the sponsor had consult this guideline before designing the study . Gir is the glucose-infusion rate.

❝ Just to clarify: Are you interested in the yellow area?

[image]


❝ Doesn’t look like your GIR cause that’s a PK profile but you get the idea. IIRC, this was called AUCapical by the “Two Lászlós” (Endrényi and Tóthfalusi). Have to dig it out.


I need to know time to 50% of GIR-AUC0-8. At the begining, I think that I can use summary table from Phoenix resluts and the function of AUC to get this time, but I am not sure whether this idea is right.
I have search many meterials about glucose-infsion study, this parameter is the secondary end. So it is a common parameter in glucose-infsion study, but I can not find the calculating mathod.:-(

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