AUC-apical? [Software]

posted by Helmut Homepage – Vienna, Austria, 2019-10-07 18:58 (1329 d 02:07 ago) – Posting: # 20676
Views: 3,358

Hi Ashima,

BTW, are you referring to this guideline?

❝ But I want to know t50% AUC(0-8h) (time to 50% of AUC, and my last sample was scheduled at 8 hours).


Just to clarify: Are you interested in the yellow area?

[image]


Doesn’t look like your GIR cause that’s a PK profile but you get the idea. IIRC, this was called AUCapical by the “Two Lászlós” (Endrényi and Tóthfalusi). Have to dig it out.

Or this one?

[image]


❝ So next what should I do if I know HVD?


Both are not easy to calculate because HVD is the difference between the two intersections times which you don’t get in Phoenix. I suggest to register at Certara’s forum and post an example project containing the data of one subject.

Ideas:

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,614 posts in 4,740 threads, 1,609 registered users;
19 visitors (1 registered, 18 guests [including 8 identified bots]).
Forum time: 21:06 CEST (Europe/Vienna)

For every fact
there is an infinity of hypotheses.    Robert M. Pirsig

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5