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RegisterAUC-apical? [Software]
posted by Helmut 
– Vienna, Austria, 2019-10-07 16:58 – Posting: # 20676
Views: 262
Hi Ashima,
BTW, are you referring to this guideline?
» But I want to know t50% AUC(0-8h) (time to 50% of AUC, and my last sample was scheduled at 8 hours).
Just to clarify: Are you interested in the yellow area?
Doesn’t look like your GIR cause that’s a PK profile but you get the idea. IIRC, this was called AUCapical by the “Two Lászlos” (Endrényi and Tóthfalusi). Have to dig it out.
Or this one?
» So next what should I do if I know HVD?
Both are not easy to calculate because HVD is the difference between the two intersections times which you don’t get in Phoenix. I suggest to register at Certara’s forum and post an example project containing the data of one subject.
Ideas:
BTW, are you referring to this guideline?
» But I want to know t50% AUC(0-8h) (time to 50% of AUC, and my last sample was scheduled at 8 hours).
Just to clarify: Are you interested in the yellow area?
![[image]](img/uploaded/image621.png)
Doesn’t look like your GIR cause that’s a PK profile but you get the idea. IIRC, this was called AUCapical by the “Two Lászlos” (Endrényi and Tóthfalusi). Have to dig it out.
Or this one?
![[image]](img/uploaded/image622.png)
» So next what should I do if I know HVD?
Both are not easy to calculate because HVD is the difference between the two intersections times which you don’t get in Phoenix. I suggest to register at Certara’s forum and post an example project containing the data of one subject.
Ideas:
- Modify one of the R-scripts of this thread and call them from Phoenix.
- Preliminary NCA (where we calculated 50%Cmax and 75%Cmax) > Final Parameters Pivoted > Data Wizard > Exclude Cmax_75
Custom Function: New Column Name: Baseline, Formula: 0
Properties: Cmax > Max_Response, Cmax_2 > Threshold
Rename the Data Wizard to PD limits
Set up another NCA-object > Options > Model Type Drug Effect (220)
Therapeutic Response > Drag/drop the Results of PD limits (the mapping should be recognized)
When you execute the NCA-Object you get
AUC_Above_T
AUC_Below_T
AUC_Net_T
I have to figure out which is what (in my example the last was negative).
—
Cheers,
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. ☼
Science Quotes
Cheers,
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. ☼
Science Quotes
Complete thread:
- how to get t50%GIR-AUC(0-8h) in winnolin? Aisha.ma 2019-10-07 07:46 [Software]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- POT-50 Helmut 2019-10-07 09:52
- POT-50 Aisha.ma 2019-10-07 16:12
- AUC-apical? Helmut 2019-10-07 16:58
- AUC-apical? Aisha.ma 2019-10-07 18:43
- Define your terms! Helmut 2019-10-07 18:54
- Define your terms! Aisha.ma 2019-10-07 19:02
- Define your terms! nobody 2019-10-08 10:51
- Define your terms! Aisha.ma 2019-10-07 19:02
- Define your terms! Helmut 2019-10-07 18:54
- AUC-apical? Aisha.ma 2019-10-07 18:43
- AUC-apical? Helmut 2019-10-07 16:58
- POT-50 Aisha.ma 2019-10-07 16:12
- POT-50 Helmut 2019-10-07 09:52
Ing. Helmut Schütz