AUC-apical? [Software]

posted by Helmut Homepage – Vienna, Austria, 2019-10-07 16:58 (662 d 13:00 ago) – Posting: # 20676
Views: 2,643

Hi Ashima,

BTW, are you referring to this guideline?

» But I want to know t50% AUC(0-8h) (time to 50% of AUC, and my last sample was scheduled at 8 hours).

Just to clarify: Are you interested in the yellow area?

[image]


Doesn’t look like your GIR cause that’s a PK profile but you get the idea. IIRC, this was called AUCapical by the “Two Lászlós” (Endrényi and Tóthfalusi). Have to dig it out.

Or this one?

[image]


» So next what should I do if I know HVD?

Both are not easy to calculate because HVD is the difference between the two intersections times which you don’t get in Phoenix. I suggest to register at Certara’s forum and post an example project containing the data of one subject.

Ideas:

Dif-tor heh smusma 🖖
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
21,594 posts in 4,515 threads, 1,532 registered users;
online 11 (0 registered, 11 guests [including 4 identified bots]).
Forum time: Saturday 05:58 CEST (Europe/Vienna)

Restlessness is discontent –
and discontent is the first necessity of progress.
Show me a thoroughly satisfied man 
and I will show you a failure.    Thomas Alva Edison

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5