Bioequivalence and Bioavailability Forum • Is ƒ2 dead as well

Is ƒ2 dead as well – always bootstrapping? [Dissolution / BCS / IVIVC]

posted by ElMaestro – Belgium?, 2019-10-06 17:54 – Posting: # 20668
Views: 302

Hi Hötzi,

» Do I get this right? Bootstrapping is preferred over ƒ₂ even if the validity criteria* are met?

I think yours is the right interpretation.
And it is free of cost, right? You have free software to do the calculation albeit the validation steps may be a bit cumbersome if you decide to go for that. It is quite uncomplicated: once you have your dissolution datasets you do the f2 and you do some bootstapping with one extra click, wait a few minutes or hours (or just split seconds if you are using my software, made in C of course) and Bob's your uncle.

—
I could be wrong, but...
Best regards,
ElMaestro

Complete thread:

EMA: Mahalanobis distance is dead... Helmut 2018-11-09 18:01 [Dissolution / BCS / IVIVC]
- EMA: Mahalanobis distance is dead... ElMaestro 2018-11-09 19:12
  - Is ƒ2 dead as well – always bootstrapping? Helmut 2019-10-06 15:27
    - Is ƒ2 dead as well – always bootstrapping? ElMaestro 2019-10-06 17:54
      - Ahem – number of units? Helmut 2019-10-06 18:14
        
        Ahem – number of units? ElMaestro 2019-10-06 22:45
        
        Ahem – number of units? wienui 2019-10-07 19:11