Two 2x2 and one 6x3 crossover design [Design Issues]

posted by qzhou – China, 2019-09-24 02:20  – Posting: # 20643
Views: 1,311

Dear Helmut,

Regarding 6x3 crossover design (with one treatment T and two references R1 and R2), I learned that “Two‐at‐a‐Time Principle” is superior most of time than Pooled ANOVA. Would you evaluate the advantages of two independent 2x2 trials (T vs. R1 and T vs. R2) over the 6x3 crossover design? Actually I have completed the two 2x2 trials. However, someone has challenged me for not conducting it as in 6x3 crossover. Could you please help?

Many thanks,


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