Bioequivalence and Bioavailability Forum • Almost entirely OT

Almost entirely OT [Bioanalytics]

posted by Helmut – Vienna, Austria, 2019-09-19 19:22 (2061 d 09:55 ago) – Posting: # 20625
Views: 9,207

Hi nobody,

❝ Without that defined it's hard to jump to conclusions regarding the concentrations you determine, let alone the pk parameters you calculate from these.

Plus: Mickey-Mouse-Pharmacokineticists (© Nick Holford) at work who trust in the “Best Fit” Al Gore Rhythm of Phoenix WinNonlin. A goody I received today (usual half-life 13 hours).

[image]

Was a 4-period full replicate. By chance the other half-lives of those subjects were better fitted and in the range of other subjects.

❝ […] But I don't think that a good analytical method and a good analytical chemist can't handle the exception from this rule (if necessary and justified)...

Cannot agree more. “Good analytical chemists” are an endangered species in those days of guidances, SOPs, and follow-the-book-believers.

To propose that poor design can be corrected by subtle analysis techniques
is contrary to good scientific thinking. Stuart J. Pocock

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Crossover: samples of p1 and p2 in different batches? Ravuri sindhura 2019-09-18 19:16 [Bioanalytics]
- Crossover: samples of p1 and p2 in different batches? dshah 2019-09-19 09:16
  - Leads to a (pseudo-) period effect Helmut 2019-09-19 15:33
    - Leads to a (pseudo-) period effect ? Ohlbe 2019-09-19 15:50
      - Leads to a (pseudo-) period effect ? Helmut 2019-09-19 15:59
        
        Leads to a (pseudo-) period effect ? nobody 2019-09-19 16:21
        
        Almost entirely OTHelmut 2019-09-19 17:22
        
        Almost entirely OT nobody 2019-09-19 17:46
        
        Completely OT Helmut 2019-09-19 18:08
        
        Leads to a (pseudo-) period effect ? dshah 2019-09-20 07:52
        
        Leads to a (pseudo-) period effect ? nobody 2019-09-20 08:00
        Run ≠ batch? Helmut 2019-09-20 09:42
        
        Run ≠ batch Ohlbe 2019-09-20 10:37
        Run ≠ batch? dshah 2019-09-23 07:43
        
        Run ≠ batch? nobody 2019-09-23 08:36
    - Leads to a (pseudo-) period effect Ravuri sindhura 2019-09-23 13:04