Almost entirely OT [Bioanalytics]

posted by Helmut Homepage – Vienna, Austria, 2019-09-19 17:22  – Posting: # 20625
Views: 950

Hi nobody,

» Without that defined it's hard to jump to conclusions regarding the concentrations you determine, let alone the pk parameters you calculate from these.

Plus: Mickey-Mouse-Pharmacokineticists (© Nick Holford) at work who trust in the “Best Fit” Al Gore Rhythm of Phoenix WinNonlin. A goody I received today (usual half-life 13 hours).

[image]


Was a 4-period full replicate. By chance the other half-lives of those subjects were better fitted and in the range of other subjects.

» […] But I don't think that a good analytical method and a good analytical chemist can't handle the exception from this rule (if necessary and justified)...

Cannot agree more. “Good analytical chemists” are an endangered species in those days of guidances, SOPs, and follow-the-book-believers.

To propose that poor design can be corrected by subtle analysis techniques
is contrary to good scientific thinking.
    [image] Stuart J. Pocock

Cheers,
Helmut Schütz
[image]

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