Leads to a (pseudo-) period effect ? [Bioanalytics]

posted by Helmut Homepage – Vienna, Austria, 2019-09-19 15:59  – Posting: # 20621
Views: 1,232

Dear Ohlbe,

» Would they really ? I would say yes if he had systematically a negative bias for period 1 and a positive bias for period 2, or vice-versa. As there will not be a single run for Period 1 samples and a single run for period 2 samples, that will not necessarily be the case: some subjects will get artificially a positive bias in P1, others in P2.

Now you confused me (even reading Ravuri’s OP again did not help). If periods are analyzed in single, separate batches it should not matter in a crossover due to the randomization. Prerequisite: Always keep the order of the batches for all subjects p1 → p2 → …

What would not work:

Cheers,
Helmut Schütz
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