Leads to a (pseudo-) period effect ? [Bioanalytics]

posted by Helmut Homepage – Vienna, Austria, 2019-09-19 15:59  – Posting: # 20621
Views: 2,697

Dear Ohlbe,

» Would they really ? I would say yes if he had systematically a negative bias for period 1 and a positive bias for period 2, or vice-versa. As there will not be a single run for Period 1 samples and a single run for period 2 samples, that will not necessarily be the case: some subjects will get artificially a positive bias in P1, others in P2.

Now you confused me (even reading Ravuri’s OP again did not help). If periods are analyzed in single, separate batches it should not matter in a crossover due to the randomization. Prerequisite: Always keep the order of the batches for all subjects p1 → p2 → …

What would not work:

Cheers,
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
20,641 posts in 4,327 threads, 1,437 registered users;
online 36 (1 registered, 35 guests [including 12 identified bots]).
Forum time: 11:24 CEST (Europe/Vienna)

I have had my results for a long time:
but I do not yet know how I am to arrive
at them.    Carl Friedrich Gauß

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5