Leads to a (pseudo-) period effect ? [Bioanalytics]

posted by Ohlbe – France, 2019-09-19 15:50 (396 d 18:51 ago) – Posting: # 20620
Views: 3,724

Dear Helmut,

» However, if Ravuri would have different responses in his approach, they would show up in the ANOVA as a period effect – which is automatically corrected for and thus not relevant in assessing the treatment effect.

Would they really ? I would say yes if he had systematically a negative bias for period 1 and a positive bias for period 2, or vice-versa. As there will not be a single run for Period 1 samples and a single run for period 2 samples, that will not necessarily be the case: some subjects will get artificially a positive bias in P1, others in P2.

Regards
Ohlbe

Complete thread:

Activity
 Admin contact
21,165 posts in 4,410 threads, 1,474 registered users;
online 11 (1 registered, 10 guests [including 5 identified bots]).
Forum time: Tuesday 10:42 CEST (Europe/Vienna)

In theory, there is no difference between theory and practice.
But, in practice, there is.    Jan L.A. van de Snepscheut

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5