Leads to a (pseudo-) period effect ? [Bioanalytics]

posted by Ohlbe – France, 2019-09-19 15:50 (374 d 09:55 ago) – Posting: # 20620
Views: 3,641

Dear Helmut,

» However, if Ravuri would have different responses in his approach, they would show up in the ANOVA as a period effect – which is automatically corrected for and thus not relevant in assessing the treatment effect.

Would they really ? I would say yes if he had systematically a negative bias for period 1 and a positive bias for period 2, or vice-versa. As there will not be a single run for Period 1 samples and a single run for period 2 samples, that will not necessarily be the case: some subjects will get artificially a positive bias in P1, others in P2.

Regards
Ohlbe

Complete thread:

Activity
 Admin contact
21,079 posts in 4,396 threads, 1,468 registered users;
online 3 (0 registered, 3 guests [including 3 identified bots]).
Forum time: Monday 01:46 CEST (Europe/Vienna)

A central lesson of science is that to understand complex issues
(or even simple ones), we must try to free our minds of dogma and
to guarantee the freedom to publish, to contradict, and to experiment.
Arguments from authority are unacceptable.    Carl Sagan

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5