Bioequivalence and Bioavailability Forum • Crossover: samples of p1 and p2 in different batches?

Crossover: samples of p1 and p2 in different batches? [Bioanalytics]

posted by dshah – India/United Kingdom, 2019-09-19 11:16 (1674 d 16:25 ago) – Posting: # 20616
Views: 6,017

No. As per the guideline- all the study samples from subjects should be analyzed in single run. If we choose different run, then there is high possibility of getting slight different calibration curve equation and thus finally concentration for the unknown samples. Thus it could have direct impact on BE.

Edit: Please follow the Forum’s Policy. [Helmut]

Complete thread:

Crossover: samples of p1 and p2 in different batches? Ravuri sindhura 2019-09-18 19:16
- Crossover: samples of p1 and p2 in different batches?dshah 2019-09-19 09:16
  - Leads to a (pseudo-) period effect Helmut 2019-09-19 15:33
    - Leads to a (pseudo-) period effect ? Ohlbe 2019-09-19 15:50
      - Leads to a (pseudo-) period effect ? Helmut 2019-09-19 15:59
        
        Leads to a (pseudo-) period effect ? nobody 2019-09-19 16:21
        
        Almost entirely OT Helmut 2019-09-19 17:22
        
        Almost entirely OT nobody 2019-09-19 17:46
        
        Completely OT Helmut 2019-09-19 18:08
        
        Leads to a (pseudo-) period effect ? dshah 2019-09-20 07:52
        
        Leads to a (pseudo-) period effect ? nobody 2019-09-20 08:00
        Run ≠ batch? Helmut 2019-09-20 09:42
        
        Run ≠ batch Ohlbe 2019-09-20 10:37
        Run ≠ batch? dshah 2019-09-23 07:43
        
        Run ≠ batch? nobody 2019-09-23 08:36
    - Leads to a (pseudo-) period effect Ravuri sindhura 2019-09-23 13:04