Bioequivalence and Bioavailability Forum • Software validation, another round

Software validation, another round [Dissolution / BCS / IVIVC]

posted by amer – Australia, 2019-09-12 07:26 (2048 d 05:25 ago) – Posting: # 20590
Views: 8,924

❝ :lol3: I’m always a little bit skeptic when one tries to validate own code (including f**ing expensive “validation packs” sold by vendors of commercial software). Hence, we have to find another one. Cross-validation would do.

I may be able to validate wagner-nelson in ivivc for R (assumes 1-comp model) with numerical deconvolution/convolution using RIVIVC package (no asumption about model structure) but there isn't enough hours in the day. will do at some stage.

suggestion: the ivivc for R can be updated to do numerical deconvolution/convolution option because what if the disposition is not 1 comp, then wanger-nelson is limited.

Complete thread:

predicting in vivo PK profiles from in vitro data after establishing IVIVC amer 2019-09-09 05:04 [Dissolution / BCS / IVIVC]
- external predictability for ivivc yjlee168 2019-09-09 10:46
  - external predictability for ivivc amer 2019-09-10 02:31
    - identical pH Helmut 2019-09-10 10:58
      - identical pH yjlee168 2019-09-10 15:30
    - R scripts/codes for in-vivo conc. yjlee168 2019-09-10 15:13
      - Software validation, another round Helmut 2019-09-10 15:37
        
        Deconvolution mittyri 2019-09-10 15:54
        Software validation, another round yjlee168 2019-09-11 10:29
        
        Software validation, another round Helmut 2019-09-11 13:39
        
        Software validation, another roundamer 2019-09-12 05:26
        
        Should we also consider to validate the validation? yjlee168 2019-09-12 09:46
        
        Who inspects the inspectors? Helmut 2019-09-13 12:07
        
        Who inspects the inspectors? nobody 2019-09-13 12:55
        
        Sapienti sat Helmut 2019-09-13 12:59
      - R scripts/codes for in-vivo conc. amer 2019-09-11 05:35
        
        Bioavailabity term in predicted in-vivo conc. yjlee168 2019-09-11 10:16