Log in
RegisterSoftware validation, another round [Dissolution / BCS / IVIVC]
» 
I’m always a little bit skeptic when one tries to validate own code (including f**ing expensive “validation packs” sold by vendors of commercial software). Hence, we have to find another one. Cross-validation would do.
I may be able to validate wagner-nelson in ivivc for R (assumes 1-comp model) with numerical deconvolution/convolution using RIVIVC package (no asumption about model structure) but there isn't enough hours in the day. will do at some stage.
suggestion: the ivivc for R can be updated to do numerical deconvolution/convolution option because what if the disposition is not 1 comp, then wanger-nelson is limited.
I’m always a little bit skeptic when one tries to validate own code (including f**ing expensive “validation packs” sold by vendors of commercial software). Hence, we have to find another one. Cross-validation would do.I may be able to validate wagner-nelson in ivivc for R (assumes 1-comp model) with numerical deconvolution/convolution using RIVIVC package (no asumption about model structure) but there isn't enough hours in the day. will do at some stage.
suggestion: the ivivc for R can be updated to do numerical deconvolution/convolution option because what if the disposition is not 1 comp, then wanger-nelson is limited.
Complete thread:
- predicting in vivo PK profiles from in vitro data after establishing IVIVC amer 2019-09-09 05:04 [Dissolution / BCS / IVIVC]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- external predictability for ivivc yjlee168 2019-09-09 10:46
- external predictability for ivivc amer 2019-09-10 02:31
- identical pH Helmut 2019-09-10 10:58
- identical pH yjlee168 2019-09-10 15:30
- R scripts/codes for in-vivo conc. yjlee168 2019-09-10 15:13
- Software validation, another round Helmut 2019-09-10 15:37
- Deconvolution mittyri 2019-09-10 15:54
- Software validation, another round yjlee168 2019-09-11 10:29
- Software validation, another round Helmut 2019-09-11 13:39
- Software validation, another roundamer 2019-09-12 05:26
- Should we also consider to validate the validation? yjlee168 2019-09-12 09:46
- Who inspects the inspectors? Helmut 2019-09-13 12:07
- Who inspects the inspectors? nobody 2019-09-13 12:55
- Sapienti sat Helmut 2019-09-13 12:59
- Who inspects the inspectors? nobody 2019-09-13 12:55
- Who inspects the inspectors? Helmut 2019-09-13 12:07
- Should we also consider to validate the validation? yjlee168 2019-09-12 09:46
- Software validation, another roundamer 2019-09-12 05:26
- Software validation, another round Helmut 2019-09-11 13:39
- R scripts/codes for in-vivo conc. amer 2019-09-11 05:35
- Bioavailabity term in predicted in-vivo conc. yjlee168 2019-09-11 10:16
- Software validation, another round Helmut 2019-09-10 15:37
- identical pH Helmut 2019-09-10 10:58
- external predictability for ivivc amer 2019-09-10 02:31
- external predictability for ivivc yjlee168 2019-09-09 10:46
Ing. Helmut Schütz