Bioequivalence and Bioavailability Forum • Evaluation of Heparin as a potentially interfering substance

Evaluation of Heparin as a potentially interfering substance [Bioanalytics]

posted by nobody – 2019-09-11 21:32 (2045 d 10:46 ago) – Posting: # 20586
Views: 3,648

Heparin is a polyanion, so: Calculate the amount instilled, the volume of fresh blood used to "flush" this amount to the blood collecting device, the resulting concentration in the blood/plasma sample. Use common sense to asses these numbers.

If in doubt (due to physico-chemical properties of analyte), do some in vitro studies with fresh blood/heparin.

—
Kindest regards, nobody

Complete thread:

Evaluation of Heparin as a potentially interfering substance Monic 2019-09-11 14:04 [Bioanalytics]
- Evaluation of Heparin as a potentially interfering substance ElMaestro 2019-09-11 18:06
  - Evaluation of Heparin as a potentially interfering substancenobody 2019-09-11 19:32
    - Evaluation of Heparin as a potentially interfering substance ElMaestro 2019-09-11 21:25