Evaluation of Heparin as a potentially interfering substance [Bioanalytics]

posted by ElMaestro  – Denmark, 2019-09-11 18:06 (585 d 17:35 ago) – Posting: # 20585
Views: 1,825

Hi Monic,

this is actually a pretty good question, in my opinion. I don't have a good answer, unfortunately. I can only offer to ramble a bit.

You give a tiny amount of Hep in the catheter with the intent to keep it exactly there. No Hep is intended to be injected/infused into the blood stream. Yet, there will of course be some diffusion.
Although the level of circulatory Hep will be low, who knows if they could interfere?

I have seen on several occasions how catheters may get clogged. In those cases the phlebotomist may do multiple push/pulls with Hep solution to clear the passage (and the subject will flinch in pain, but that is another story).
In those cases, surely you will get much more Hep into the blood stream. Will you get enough to interfere? My gut feeling says "no", but who am I to actually qualify that? May even be depending on the type of Hep, who knows?!?
There is other stuff in the Hep solution, most often Glucose but sometimes there is a gelling agent, because this solution has to be much like a marmelade to serve its purpose. So what about that gelling agent?

Technicality: Hep is not infused during sampling. It is only instilled in the catheter. This, I assume, is also what you meant.

Pass or fail!

Complete thread:

 Admin contact
21,419 posts in 4,475 threads, 1,510 registered users;
online 16 (0 registered, 16 guests [including 3 identified bots]).
Forum time: Monday 11:42 CEST (Europe/Vienna)

There is one certainty in drug development
and statistics that one can depend on:
the data are always late.    Scott Patterson and Byron Jones

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz