Bioavailabity term in predicted in-vivo conc. [Dissolution / BCS / IVIVC]

posted by yjlee168 Homepage – Kaohsiung, Taiwan, 2019-09-11 08:16 (642 d 18:26 ago) – Posting: # 20581
Views: 4,503

Hi amer,

Nice question. Oral bioavailability term (F) has been presented as predicted Fab (PFab, predicted fraction absorbed, %) obtained from ivivc model (Levy plots) in the equation of Pcp. Here is the ref.: M Gohel, RR Delvadia, DC Parikh, et. al., Simplified Mathematical Approach for Back Calculation in Wagner-Nelson Method. See equation (1.5).

» ... however, i don't see the oral bioavailability term in the [PCp] equation in the R-code provided. Shouldn't that include bioavailability when doing convolution? Does it assume, in its current for, that the bioavailability is 100%?

All the best,
-- Yung-jin Lee
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