Bioequivalence and Bioavailability Forum • Bioavailabity term in predicted in-vivo conc.

Bioavailabity term in predicted in-vivo conc. [Dissolution / BCS / IVIVC]

posted by yjlee168 – Kaohsiung, Taiwan, 2019-09-11 12:16 (1542 d 15:08 ago) – Posting: # 20581
Views: 5,880

Hi amer,

Nice question. Oral bioavailability term (F) has been presented as predicted Fab (PFab, predicted fraction absorbed, %) obtained from ivivc model (Levy plots) in the equation of Pcp. Here is the ref.: M Gohel, RR Delvadia, DC Parikh, et. al., Simplified Mathematical Approach for Back Calculation in Wagner-Nelson Method. See equation (1.5).

❝ ... however, i don't see the oral bioavailability term in the [PCp] equation in the R-code provided. Shouldn't that include bioavailability when doing convolution? Does it assume, in its current for, that the bioavailability is 100%?

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Complete thread:

predicting in vivo PK profiles from in vitro data after establishing IVIVC amer 2019-09-09 05:04 [Dissolution / BCS / IVIVC]
- external predictability for ivivc yjlee168 2019-09-09 10:46
  - external predictability for ivivc amer 2019-09-10 02:31
    - identical pH Helmut 2019-09-10 10:58
      - identical pH yjlee168 2019-09-10 15:30
    - R scripts/codes for in-vivo conc. yjlee168 2019-09-10 15:13
      - Software validation, another round Helmut 2019-09-10 15:37
        
        Deconvolution mittyri 2019-09-10 15:54
        Software validation, another round yjlee168 2019-09-11 10:29
        
        Software validation, another round Helmut 2019-09-11 13:39
        
        Software validation, another round amer 2019-09-12 05:26
        
        Should we also consider to validate the validation? yjlee168 2019-09-12 09:46
        
        Who inspects the inspectors? Helmut 2019-09-13 12:07
        
        Who inspects the inspectors? nobody 2019-09-13 12:55
        
        Sapienti sat Helmut 2019-09-13 12:59
      - R scripts/codes for in-vivo conc. amer 2019-09-11 05:35
        
        Bioavailabity term in predicted in-vivo conc.yjlee168 2019-09-11 10:16