Bioequivalence and Bioavailability Forum

R scripts/codes for in-vivo conc. [Dissolution / BCS / IVIVC]

posted by amer – Australia, 2019-09-11 05:35  – Posting: # 20580
Views: 1,231

Hi Lee,

» I don't know if this is what you want. Let me know you still have question about running the codes. I have tested the codes and it works well.

Thanks very much. Yes, it is;however, i don't see the oral bioavailability term in the [PCp] equation in the R-code provided. Shouldn't that include bioavailability when doing convolution? Does it assume, in its current for, that the bioavailability is 100%?

» » on the side, just wondering if the ivivc package been validated against standard ivivc software (say WinNonlin?)
»
» Not validated with WLN. Should I? I do not have WLN. If you have WNL, can you help to validate?

Unfortunately, i dont have access to WLN.

Cheers,

Complete thread:

• predicting in vivo PK profiles from in vitro data after establishing IVIVC amer 2019-09-09 05:04 [Dissolution / BCS / IVIVC] 
  • external predictability for ivivc yjlee168 2019-09-09 10:46
    • external predictability for ivivc amer 2019-09-10 02:31
      • identical pH Helmut 2019-09-10 10:58
        • identical pH yjlee168 2019-09-10 15:30
      • R scripts/codes for in-vivo conc. yjlee168 2019-09-10 15:13
        • Software validation, another round Helmut 2019-09-10 15:37
          • Deconvolution mittyri 2019-09-10 15:54
          • Software validation, another round yjlee168 2019-09-11 10:29
            • Software validation, another round Helmut 2019-09-11 13:39
              • Software validation, another round amer 2019-09-12 05:26
                • Should we also consider to validate the validation? yjlee168 2019-09-12 09:46
                  • Who inspects the inspectors? Helmut 2019-09-13 12:07
                    • Who inspects the inspectors? nobody 2019-09-13 12:55
                      • Sapienti sat Helmut 2019-09-13 12:59
        • R scripts/codes for in-vivo conc.amer 2019-09-11 05:35
          • Bioavailabity term in predicted in-vivo conc. yjlee168 2019-09-11 10:16