Bioequivalence and Bioavailability Forum • Deconvolution

Deconvolution [Dissolution / BCS / IVIVC]

posted by mittyri – Russia, 2019-09-10 17:54 (1829 d 11:57 ago) – Posting: # 20579
Views: 7,234

Hi Helmut,

❝ If you want to perform cross-validation that would require a couple of reference datasets and hope for the same outcome.

the probability is close to nil due to a nightmare called deconvolution...

—
Kind regards,
Mittyri

Complete thread:

predicting in vivo PK profiles from in vitro data after establishing IVIVC amer 2019-09-09 05:04 [Dissolution / BCS / IVIVC]
- external predictability for ivivc yjlee168 2019-09-09 10:46
  - external predictability for ivivc amer 2019-09-10 02:31
    - identical pH Helmut 2019-09-10 10:58
      - identical pH yjlee168 2019-09-10 15:30
    - R scripts/codes for in-vivo conc. yjlee168 2019-09-10 15:13
      - Software validation, another round Helmut 2019-09-10 15:37
        
        Deconvolutionmittyri 2019-09-10 15:54
        Software validation, another round yjlee168 2019-09-11 10:29
        
        Software validation, another round Helmut 2019-09-11 13:39
        
        Software validation, another round amer 2019-09-12 05:26
        
        Should we also consider to validate the validation? yjlee168 2019-09-12 09:46
        
        Who inspects the inspectors? Helmut 2019-09-13 12:07
        
        Who inspects the inspectors? nobody 2019-09-13 12:55
        
        Sapienti sat Helmut 2019-09-13 12:59
      - R scripts/codes for in-vivo conc. amer 2019-09-11 05:35
        
        Bioavailabity term in predicted in-vivo conc. yjlee168 2019-09-11 10:16

Admin contact
23,223 posts in 4,877 threads, 1,655 registered users;
28 visitors (0 registered, 28 guests [including 6 identified bots]).
Forum time: 05:52 CEST (Europe/Vienna)

One of the symptoms of an approaching nervous breakdown
is the belief that one’s work is terribly important. Bertrand Russell

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC

Ing. Helmut Schütz