## Software validation, another round [Dissolution / BCS / IVIVC]

Hi Yung-jin and amer,

» » on the side, just wondering if the ivivc package been validated against standard ivivc software (say WinNonlin?)
»
» Not validated with WLN. Should I? I do not have WLN. If you have WNL, can you help to validate?

Since the source code of ivivc for R is accessible, one can perform a validation. Requires an expert R-coder who is also knowledgeable with the scientific background of IVIVC. An incredibly rare species. Commercial software like the ‘IVIVC Toolkit’ of Phoenix can only be validated. If you want to perform cross-validation that would require a couple of reference datasets and hope for the same outcome.

@Yung-jin: Though Certara granted me with a ‘named license’ of Phoenix’ ‘IVIVC Toolkit’, I never used it so far. Furthermore, my experience with ivivc for R are zero.

Cheers,
Helmut Schütz

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